Munich's multi-level Franz-Josef-Strauss Flughafen (airport) is only slightly less busy than Frankfurt's mega flughafen, but it's way less intimidating. Flights bound for Europe, New York and Sydney jet in and out, either direct or via Frankfurt, and a host of German cities are served by at least six flights daily. Departure tax is included in the ticket price, as are airport security fees.
There are rapid train connections every two hours or so to all major German cities, and frequent services to European cities like Vienna, Prague, Zürich, Rome and Paris.
Driving to Munich along Germany's excellent roads can be fun, but your car will be next to useless once you've arrived. Boat/car/train/bus combos are another possibility: ferries go between Germany and the UK, Sweden, Denmark, Norway and Finland.
Getting from museum A to beer hall Z is simple: either promenade with the Müncheners along the central pedestrian zone from the Hauptbahnhof to Marienplatz or catch a ride on Munich's excellent public transport network (MVV). The system is zone-based and most places of interest are within the inner-city white zone. The underground will get you to most of the sights, with buses filling in the gaps. A novel but expensive way to get around is via pedicabs. You can also cycle your way around the city.